siERG-affected genes in EC1 and EC2 were enriched in COVID-19 adverse outcome pathway (Zhang et al., 2022) (WP4891; p-values 5 × 10–9 and 8.3 × 10–5, for EC1-2, respectively) and AGE-RAGE signaling in diabetes (Deng et al., 2020) (hsa04933; p-values 8.9 × 10–16 and 1.9 × 10–20, respectively), while EC3 siERG-perturbed genes are enriched with a unique metabolic profile demonstrated by enrichment in monosaccharide metabolic process (GO:0005996; p-value 1 × 10–6), carbohydrate metabolic process (GO:0005975; p-value 6.6 × 10–7), and aerobic glycolysis (WP4629; p-value 4.1 × 10–5) (Figure 4D). This evidence concerns the gene RENBP and diabetes mellitus.