Of the 850,000 methylation sites analyzed, distributed throughout the genome, 27 were identified (18 of them corresponding to the genes FMNL2, METTL3, ACOT6, SCARNA20, PREX1, DNAI2, RAET1G, KCNJ8, GDF7, SYNPO2, CUGBP1, FRMD8, MKL2, HIF1A, TMEM177, UTP23, PXK and TNPO1) that were associated with the development of early tumor shrinkage secondary to BVZ. The gene discussed is TNPO1; the disease is neoplasm.