GAS6 and Bloom syndrome: Simultaneously, BLM-induced the levels of PGE2 and PGD2 in BAL fluid and conditioned media from ATII cells and alveolar macrophages were reduced in Gas6−/− mice (Fig. 7f and g), but the hydroxyproline amount in lung tissue from Gas6−/− mice was further enhanced compared with that in WT control mice (Fig. 8a).