For example, the blocking of CCL2 can inhibit metastasis of tumors (Alieva et al. 2017) and interrupt the CXCR4/CXCL12 chemokine axis, which can be used to sensitize drug-resistant tumor cells to chemotherapy or radiotherapy and may inhibit angiogenesis and proliferation of tumor cell. This evidence concerns the gene CXCL12 and neoplasm.