TGFB1 and breast carcinoma: Edward Gitau Mathenge et al. showed that in breast cancer incision biopsy, the expression of TGF-β and SRY-Box Transcription Factor 4 (SOX4) was significantly increased in tumors after biopsy, participating in the SOX4/EZH2 EMT pathway initiated by TGF-β (Mathenge et al. 2014).