CTLA4 and neoplasm: Treg cells can also participate in Treg-mediated tumor immunosuppression through a variety of molecules, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), IL-2, IL-10, TGF-β, IL-35, glucocorticoid-induced tumor necrosis factor receptor (glucocorticoid TNF receptor), lymphocyte activation gene 3 (LAG3), granzyme B, adenosine, and cyclic adenosine monophosphate (CAMP6) (Tanaka and Sakaguchi 2017; Sakaguchi et al. 2008).