Interrogating expression of individual markers, we found five notable proinflammatory analytes (Caspase-8, EN-RAGE, IL-18, MCP-3, and MMP-1) that were present at higher concentrations in the supernatants of severe COVID-19 patient monocyte cultures compared with healthy monocyte cultures (Fig. 7D). This evidence concerns the gene CASP8 and COVID-19.