Other predicted downstream targets in severe COVID-19 included several genes associated with decreased NK cell functionality [EZH2 (61), PRDM1 (62), SERPINB1 (63)], two STAT family transcription factors [STAT1, STAT2 (64)], and signaling adaptor MYD88 (65) (Fig. 2C). This evidence concerns the gene EZH2 and COVID-19.