As shown in Table 5, univariate logistic regression analysis found that age, sex, SBP, hypertension history, diabetes history, CHD history, smoking history, drinking history, CRP, FPG, HbA1c, TC, LDL‐C, homocysteine, eGFR, uric acid, and, NLR were significantly related with Lacune. This evidence concerns the gene CRP and diabetes mellitus.