We analyzed the difference of proportion between CD56+ NK cells and CD161+CD56+ NK cells in active and inactive pSS patients and HCs, and we observed that CD56+ NK cells proportion decreased in active and inactive pSS patients compared with HCs (active vs. HCs: 8.81% [5.13%–20.00%] vs. 13.75% [8.90%–26.40%], p = .002; inactive vs. HCs: 9.50% [3.05%–21.80%] vs. 13.75% [8.90%–26.40%], p = .007) (Figure 3A), but there was no statistical difference between active and inactive pSS patients (8.81% [5.13%–20.00%] vs. 9.50% [3.05%–21.80%], p = .429) (Figure 3A). This evidence concerns the gene KLRB1 and peeling skin syndrome.