Regarding the difference of CD161+CD56+ NK cells proportion in active and inactive pSS patients and HCs, we found that not only CD161+CD56+ NK cells proportion in active and inactive pSS patients was obviously lower than that in HCs (active vs. HCs: 55.04% ± 18.73% vs. 77.38% ± 10.53%, p < .0001. The gene discussed is KLRB1; the disease is peeling skin syndrome.