In pSS patients, the proportion of surface active markers CD86 and HLA‐DR on CD161+CD56+ NK cells was lower than that on CD161­−CD56+ NK cells (CD86+ cells%: 1.05% ± 0.32% vs. 5.84% ± 2.22%, p = .0014, Figure 5B; HLA‐DR+ cells%: 32.66% ± 8.70% vs. 55.54% ± 11.73%, p = .0081, Figure 5C). This evidence concerns the gene KLRB1 and peeling skin syndrome.