The effect of chronic administration of NDP-α-MSH was investigated in several mouse models of AD – in 3xTg mice, a model of AD containing three human mutations, APPSwe, presenilin 1 (PS1)M146V, and TauP301L [103,104]; in Tg2576 mice carrying the APPSWE mutation [105,106]; and in 5XFAD mice with 5 mutations connected to AD-Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PS1 [104]. The gene discussed is APP; the disease is Alzheimer disease.