TNKS and malignant colon neoplasm: The successful synthesis, characterization and analysis of the inter­molecular inter­actions of N1-(51-substituted-21-hy­droxy­benzyl­iden­yl)-N-cyclo­amino-2-sulf­anil­amides (com­pounds 17–23) have been achieved, alongside their evaluation for inhibitory effects on tankyrase poly(ADP-ribose) polymerase in the context of colon cancer through in-silico testing.