Both berberine and sanguinarine are alkaloids that haveshown potential as natural alternatives to traditional antibioticsin the treatment of infections caused by resistant microorganisms.16−20 They possess a large hydrophobic surface, which profits from hydrophobicinteractions with the hydrophobic pockets of lactoferrin,21,22 thus facilitating efficient encapsulation and modulation of theirrelease from the nanocarrier system. This evidence concerns the gene LTF and infection.