In addition to the liver function and nutritional indices noted above, etiology, AFP reduction rate, macrovascular invasion, extrahepatic spread, AEs (skin reaction, liver damage, hypertension, proteinuria), serum interleukin‐6, granulocytes expressing PD‐1, vascular endothelial growth factor, angiopoietin‐2, insulin‐like growth factor‐1, and circulating tumor DNA have been shown to be related to the outcome of Atez/Bev treatment.44 This evidence concerns the gene VEGFA and skin reaction.