Moreover, in the mice p210 BCR::ABL1‐transduced ALL model,19 in vivo conditional knockout of the integrin α6 gene sensitized the leukemia cells to nilotinib treatment, suggesting that the laminin/CD49f interaction might also be involved in the TKI‐resistance of Ph‐positive ALL. The gene discussed is ITGA6; the disease is acute lymphoblastic leukemia.