Additionally, key players in regulating glycolysis in tumor cells include oncogenes such as c-Myc, tumor suppressor genes TP53 and PTEN, Glucose transporters (GLUTs), oxygen homeostasis regulatory genes like HIF-1α, and glycolytic enzymes including HK, ENO1, LDHA, and PKM2. The gene discussed is HIF1A; the disease is neoplasm.