In addition, we found that 7 immune checkpoints (TIGIT, PDCD1LG2, PDCD1, HAVCR2, CTLA4, CD274) were highly expressed in HCC high IGF2BP3 expression group, while SIGLEC15 showed no statistical difference (Figure 6C). The gene discussed is PDCD1LG2; the disease is hepatocellular carcinoma.