In multiple myeloma (MM), the level of PHGDH expression was considerably elevated and correlated with inferior survival, and the mechanism involved may be that high levels of PHGDH reduce ROS and DNA damage by increasing intracellular glutathione, promote the survival and proliferation of MM cells, and improve tumour cell resistance to bortezomib 45. This evidence concerns the gene PHGDH and AL amyloidosis.