Their results predicted that 117,000 circRNAs could potentially associate with eIF4A3 and 9,945 of all circRNAs were predicted to be targeted by eIF4A3 in their junction sequence 7, which prompted us to explore whether eIF4A3 interacts with circRNAs to unwind secondary structure in the 5′ UTR in normal and cancer cells. The gene discussed is EIF4A3; the disease is cancer.