circular RNA circ-231 promotes protein biogenesis of TPI1 and PRDX6 through mediating the interaction of eIF4A3 with STAU1 to facilitate unwinding of secondary structure in 5′ UTR, enhancing progression of human esophageal squamous cell carcinoma (ESCC). The gene discussed is EIF4A3; the disease is esophageal squamous cell carcinoma.