Among them, high-risk genes MYBL2, C21orf62 and TUBA1C showed higher expression levels in tissues from high-grade gliomas patients (WHO IV grade, GBM), while the expression of low-risk gene KCNIP2 was relatively lower in GBM (Figure 8A-D), which is consistent with our previous hypothesis. The gene discussed is MYBL2; the disease is central nervous system cancer.