5, 6 Extensive research focusing on oncogene drivers has been conducted to investigate the regulatory mechanisms underlying the progression of LUAD. Targeted therapies have also been actively pursued. However, the complex immune microenvironment mechanism of LUAD remains poorly understood and requires further clarification. 7 NEDD1 has been suggested to exhibit upregulation in various cancer types and has the potential to serve as a diagnostic factor. Here, NEDD1 is linked to cancer.