More and more studies have revealed that ribosomal proteins are not only involved in protein synthesis,5 but also in the regulation of cell proliferation, migration invasion, apoptosis, cell cycle, and angiogenesis.6-8 RPL22L1 is a member of the ribosomal protein family and a homologous analog of RPL22.9 A increasing number of studies have demonstrated that RPL22L1 promotes to the progression of carcinoma. This evidence concerns the gene RPL22L1 and carcinoma.