CALCR and hypercalcemia disease: However, the reduction in P1NP, the reduced expressions of Sost and Bglap, and the increased expression of Calcr allow for the possibility that a small reduction in the influx of calcium into bone (via osteoblasts) or efflux of calcium out of bone (via osteoclasts) contributed to the hypercalcemia without a detectable change in the skeletal mineral content.