TPMO-AS1(L) could serve as a framework for the association between casein kinase 2α1 (CSNK2A1) and DEAD-box helicase 3 X-linked (DDX3X) leading to activation of the Wnt/β-catenin pathway, and fostering the myelodysplasia of PCa. This evidence concerns the gene DDX3X and posterior cortical atrophy.