In vivo siRNA delivery was studied in SCC-VII tumor-bearing mice intravenously infused with a 0.5 mL saline suspension of EGFR siRNA LPX (7×108 LPX, ~30 μg siRNA) for 20 min during concurrent US (1 MHz, 0.5 MPa spatial peak temporal peak negative pressure, five 100-μs pulses every 1 ms; each pulse train repeated every 2 sec to allow reperfusion of LPX into the tumor). Here, EGFR is linked to neoplasm.