As such, the application of the SIR-Profile takes into consideration the overall magnitude (Δ pre- to post-exercise) and interactions between the cluster of inflammatory cytokines (i.e. TNFα, IL-1β, IL-6, IL-8, IL-10, IL-1ra) potentially links to pathophysiology of heat stroke; which is similar to the previously reported pro- to anti-inflammatory ratio [2,3,18,19,28]. The gene discussed is IL6; the disease is Heat Stroke.