APP and Alzheimer disease: Recent research that was conducted to examine the influence of linc00507 on Tau phosphorylation in both an animal model of AD and a cell model (Aβ42-SH-SY5Y) found that linc00507 exhibited a significant increase in the hippocampus and cerebral cortex of transgenic mice expressing APP/PS and in AD-like SH-SY5Y cells.