BACE1 and Alzheimer disease: On the other side, researchers have demonstrated that lncRNAs play a significant role in the development of AD by affecting both nuclear and cytoplasmic activities, and various dysregulated of lncRNAs have been associated with AD pathogenesis, with particular lncRNAs such as BACE1-AS, NEAT1, MALAT1, and SNHG1 [12].