Conversely, lncRNA MALAT1 has been associated with neuroinflammation and has been shown to regulate microglial activation, stimulating immunological responses in Alzheimer's disease (AD) [80].LncRNA research is a fast-evolving area, and more has to be found about the involvement of lncRNAs in Alzheimer's disease. The gene discussed is MALAT1; the disease is early-onset autosomal dominant Alzheimer disease.