Considering the common metabolic defects shared by AD and T2DM, such as impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction (Carvalho and Moreira, 2023), further experiments are needed to determine whether T2DM similarly results in reduced Kir2.1 expression in the cerebral microvascular endothelium. This evidence concerns the gene KCNJ2 and Alzheimer disease.