PRRT2 and type 1 diabetes mellitus: However, studies have suggested a reduction in the functionality of Kir2.1 channels in cerebral arterioles of streptozotocin-induced T1DM rats (Mayhan et al., 2004), and this reduction is related to the increase of PKC activity caused by selective up-regulation of PKC-α (a subtype of PKC) (Vetri et al., 2013, 2017).