Among PD-related genes in the brain substantia area, ARSA (Senkevich et al., 2023), KANSL1-AS1 (Lona-Durazo et al., 2023), FAM47E (Blauwendraat et al., 2019), and ARHGAP27 (Saeed, 2018) have been reported to be risk loci that contribute to the development of PD. This evidence concerns the gene ARHGAP27 and Parkinson disease.