Many studies indicate that the onset of MOGAD is associated with a broad range of infections and vaccinations.23,24 Furthermore, recent studies suggested MOGAD to be a rare neurological post-acute sequelae after SARS-CoV-2 infection or vaccination, pointing to a possible role of both as a potential trigger of MOGAD.7-22 In this study, we therefore aimed to elucidate whether there is an immunological cross-reactivity between SARS-CoV-2 S or N proteins and MOG and to explore the relation of antibody responses against MOG and SARS-CoV-2 and other coronaviruses. Here, MOG is linked to infection.