ALDH2 and neurodegenerative disease: Aldehyde dehydrogenase 2 (ALDH2) activity is important for aldehyde metabolism, e.g. it catalyses the rate-limiting step of alcohol metabolism, and has been linked to multiple neurological and neurodegenerative diseases.44 In mice, ALDH2 regulates neuroinflammation and Aβ-levels in vivo, particularly in response to ethanol.45 Modification of this pathway, e.g. using chemical compounds related to disulfiram may, therefore, be useful in the regulation of this aspect of Alzheimer’s neuropathology.44