A PubMed literature search excluding sources outside the United States and duplicates was performed using the following search criteria: “COVID-19 AND cardiovascular disease AND ACEi AND ARB”, “SARS-COVID-19 OR COVID-19, AND ACEi AND ARB AND Infection rate”, “COVID-19 AND ACEi and ARB”, “Omicron BA.1 and BA.2 AND ACE2 OR ARBs”, “Omicron AND ACEi AND ARBs”. This evidence concerns the gene ACE2 and infection.