The clinical phenotypes of MOGAD overlap with those of NMOSD but include a wider range of presenting phenotypes including acute disseminated encephalomyelitis (ADEM), optic neuritis, myelitis, or demyelinating brain lesions; however, its clinical course and prognosis differ from those of AQP4-NMOSD (2, 3). This evidence concerns the gene AQP4 and acute disseminated encephalomyelitis.