Splenomegaly and lesions in the spleen due to infection with T. cruzi have likewise already been previously reported in a murine model and have been attributed to the activation of macrophages, NK cells, and CD8+ lymphocytes, which leads to an increase in the levels of cytokines with a pro-inflammatory Th1 profile and, at the same time, produces an uncontrolled inflammatory reaction (34, 35). The gene discussed is CD8A; the disease is infection.