TMEM135 and metabolic disease: There have been published associations with TMEM135 and other human medical conditions such as osteoporosis (122–127), breast cancer (128, 129), prostate cancer (130, 131), melanoma (132, 133), non-small lung cancer (134), glioblastoma multiforme (134), non-alcoholic fatty liver disease (135), cognitive disorders (136), and metabolic disease (25).