FASN and age-related macular degeneration: Integrated microarray and RNA-Seq datasets (GSE29801 and GSE135092) of RPE/choroid samples from AMD patients (16, 103–105) showed increased sterol regulatory element binding transcription factor 1 (SREBP1), a transcription factor required for the synthesis of fatty acids and cholesterol, and its target genes fatty acid synthase (FASN), fatty acid desaturase 1 (FADS1), and FADS2 (16).