TP53 and colonic neoplasm: Additionally, it has been reported that drug-resistant colon cancer cells highly express the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-2, and have low expression of pro-apoptotic proteins, such as P53, Bax, and Bim; Bcl-2 family proteins play an important role in the drug resistance of colon cancer cells (Fulda, 2009; Hu et al., 2016).