PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In addition, the effect of patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 protein (TM6SF2), and membrane-bound O-acyltransferase domain-containing 7 (MBOAT7) gene polymorphism provides convincing evidence for elucidating the genetic susceptibility to NAFLD (Xia et al., 2022).