To assess the colocalized expression of Hsc70 and LAMP-2A in RA-FLS cells, they were observed using the confocal method, and it was found (Figures 3G–I) that CAY10603 downregulated the expression of Hsc70 and LAMP-2A, and at the same time, inhibited the degree of colocalization of the two. This evidence concerns the gene HSPA8 and rheumatoid arthritis.