RA-FLS cell secrete a multitude of pathogenic mediators, such as cytokines (tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), which causes the migration and differentiation of other cells in the synovial membrane of RA patients, speeding up the progression RA (Leo et al., 2022). The gene discussed is IL6; the disease is rheumatoid arthritis.