IL6 and infection: Moreover, as one of the major important receptors, IL-6 plays a role as a complex whole by combining with the host defense against any attack agent of infection and damage to tissues via the ability to induce acute phase reactions and blood cell production, which also has devastating effects due to its uncontrolled increase in IL-6 production, thereby resulting in different immune-mediated developmental inflammation and diseases (McInnes and Schett, 2007; Yoshida and Tanaka, 2014).