However, extensive research now suggests that HMMR performs multiple functional roles in overseeing cell growth, the spread of cancer to other parts of the body (D. Yang et al., 2021), the preservation of cellular pluripotency (Tilghman et al., 2014), and resistance to cancer treatment (Sofi et al., 2023; H; Zhang et al., 2019) in various malignancies, such as lung carcinoma (Li W. et al., 2020), hepatic neoplasia (D. Zhang et al., 2020), urothelial carcinoma (D. Yang et al., 2021), and stomach neoplasia (Kang et al., 2020). The gene discussed is HMMR; the disease is cancer.