Upregulated expression of stemness genes such as stem cell antigen-1 (Sca-1) and MDR-1 (Matsuda et al., 2010) and aldehyde dehydrogenase (ALDH) (Ohmura-Kakutani et al., 2014) has been demonstrated in tumor endothelial cells, as a part of the tumor endothelial cell population (Nagy and Dvorak, 2012; Goveia et al., 2020). The gene discussed is LDHA; the disease is neoplasm.