Accumulated data indicated that receptor tyrosine kinases (RTKs), such as EGFR, PDGFR, FGFR, and VEGFR, and non-receptor RTKs play a critical role in the pathogenesis of renal fibrosis (Liu et al., 2015b; Liu and Zhuang, 2016; Wang et al., 2016). The gene discussed is KDR; the disease is renal fibrosis.