TGFB1 and Mental deterioration: In addition, we found that lower TGF-β1/TNF-α ratio were strongly correlated with the rate of cognitive decline at the follow-up period (12 months) assessed by the dTSI (Figure 6C, Spearman r 0.3930, p < 0.05), supporting the idea proposed about the characterization of a model fitting with the assessment of cognitive decline.