Interestingly, yarrow-Sep inhibited key lipid metabolic targets in CRC cells extensively shown to be implicated in cancer dissemination and prognosis —SREBF1, FASN, ABCA1 and HMGCR— and epithelial to mesenchymal targets—CDH1, ATP1B1, CDH2 and Vimentin—augmenting cell adhesion. Here, HMGCR is linked to colorectal carcinoma.