Some studies have reported increased levels of histone H4K16 acetylation in HGPS fibroblasts (Mattioli et al., 2018; Maynard et al., 2022), while others have shown decreased levels of H4K16 acetylation in the Zmpste24 mouse model of HGPS (Krishnan et al., 2011). Here, ZMPSTE24 is linked to Hutchinson-Gilford progeria syndrome.