We also discovered that RBM10 mutations frequently coexisted with other driver gene mutations in CCA, suggesting that the widespread transcriptome alterations triggered by RBM10 mutations might cooperate with these mutations in the advancement of CCA (KRAS, SMAD4, CTNNB1, TGFBR2, SF3B1). The gene discussed is SMAD4; the disease is cholangiocarcinoma.