SMAD4 and cholangiocarcinoma: We further analyzed the mutation patterns in the RBM10 alter group in Chinese CCA population cohort: classic tumor driver genes (KRAS, SMAD4, CTNNB1, TGFBR2, SF3B1, etc. P < 0.05) were more prone to co-occur in the RBM10 alter group (Fig. 1.