RAF1 and colorectal carcinoma: For instance, the voltage-gated potassium channel Kv1.3 is abnormally expressed in CRC [12]; the sodium channel epithelial 1 subunit beta inhibits the occurrence of CRC by suppressing the active c-Raf and mitogen-activated protein kinase signals [13]; the voltage-gated sodium channel Nav1.5 is a key regulator of the gene transcription network controlling colon cancer invasion [14]; low expression of chloride channel accessory 1 indicates a poor prognosis in CRC [15].