Notably, the protective factors included KCTD9 [59], DAPK1 [60], NOS2 [61], and SPINK4 [62], and the risk factors for poor CRC prognosis were listed as follows: ANGPTL4 [63], MMP1 [64], HOXC6 [65], EREG [66], TNNT1 [67], and CALB2. The gene discussed is SPINK4; the disease is colorectal carcinoma.