TRPV1 and neoplasm: For instance, the ion channel of the transient receptor potential cation channel subfamily V member 1 gain-of-function reprograms the immune microenvironment to promote colorectal tumorigenesis [20]; inactivation of calcium ion channels that recognize tumor antigens can affect the anti-cancer immunity of tumor cells, and the hyperpolarization of tumor cell can increase the likelihood of immune evasion and promote tumor progression [21].