Further, it has been demonstrated that the glymphatic system is involved in the clearance of amyloid-β (Aβ), the main component of the amyloid plaques found in the brains of people with AD [22, 47], and mounting evidence also links the glymphatic system with the clearance of the intracellular AD hallmark protein tau [16, 21, 23]. Here, MAPT is linked to Alzheimer disease.