The presence of aPL can be detected in more than one-third of patients with primary SS (pSS) [125], in which lupus anticoagulant (LAC) has been suggested to serve as an important marker for the development of VTE in pSS patients [126], in addition, LAC is the most valuable aPL for predicting thrombotic events in patients with CTD [127]. The gene discussed is FASLG; the disease is peeling skin syndrome.