In addition to the association with the development of cardiovascular diseases such as myocardial infarction and stroke, et al. found that there is an association between anti-citrullinated peptide 2 (CCP2) antibody positivity and the risk of VTE in patients with RA, and this risk increases with the increase in IgG anti-CCP2 levels [104]. This evidence concerns the gene AGBL2 and stroke disorder.