In addition, the integrity of the body’s vascular endothelium is damaged and a prothrombotic state is formed in response to systemic inflammatory reactions such as elevated IgM class anticardiolipin antibodies (aCL-IgM) and IgM class anti-β2-glycoprotein I antibodies (a-β2GPI-IgM) [33] in SLE patients. This evidence concerns the gene CD40LG and systemic lupus erythematosus.