Most of the included variables used to adjust the multivariate analysis were the commonly reported biomarkers (ER, PR, HER2, and Ki-67), age, tumour size and grade, age at diagnosis, lymph node stage, histological grade, body mass index (BMI), chemotherapy regimens, chemotherapy cycles, and other biomarkers and genetic variations unique to the study. This evidence concerns the gene MKI67 and neoplasm.