Compared to CRC cells treated with PBS or Ctrl-EVs, the expression of E-cadherin in CRC cells incubated with Sen-EVs was decreased, and the expression of Snail, Slug, and MMP-9 was elevated, which further suggested the promotional effect of Sen-EVs on the migration and invasion of CRC cells (Fig. 5E). The gene discussed is CDH1; the disease is colorectal carcinoma.