Moreover, compared to CRC cells cultured with PBS or Ctrl-EVs, cells cultured with Sen-EVs and Sen-EVsSERPINE1−GFP showed a significantly elevated expression of SERPINE1, which further implied SERPINE1 was enriched in Sen-EVs and could be internalized by recipient CRC cells (Fig. 6K). This evidence concerns the gene SERPINE1 and colorectal carcinoma.