Furthermore, the PheWAS analysis of a single variant, rs11264345 (the top variant identified by a genome-wide association study of osteoporosis with a P value of 8 × 10−4 in TWB), revealed significant associations with 5 health outcomes, including blood urea nitrogen (BUN), uric acid, hemoglobin (Hb), hematocrit (HCT), and bone stiffness index (Fig. 1C and Additional file 2). Here, GSTM1 is linked to osteoporosis.