Furthermore, DDR PVs are widely used as specific diagnostic markers for cancer risk prediction, e.g., BRCA1 PVs are often used as the markers to predict breast cancer risk [9] and guide cancer treatment, e.g., as the indicator for using PARP inhibitors (PARPi) to treat breast cancer with BRCA1 PVs [10]. Here, BRCA1 is linked to breast cancer.